TitleCoarse-Grained Modelling of DNA and DNA Self-Assembly
Author(s)Ouldridge, Thomas E
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2012.
DescriptionXII, 176 p : online resource
Abstract NoteThis thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker ??? the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology
Keyword(s)1. Amorphous substances 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. Complex fluids 6. COMPLEX SYSTEMS 7. DYNAMICAL SYSTEMS 8. EBOOK 9. EBOOK - SPRINGER 10. NANOTECHNOLOGY 11. Polymer Sciences 12. Polymers???? 13. Soft and Granular Matter, Complex Fluids and Microfluidics 14. STATISTICAL PHYSICS 15. Statistical Physics and Dynamical Systems
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