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21 Rahman, Masoud Protein-Nanoparticle Interactions I07681 2013 eBook  
22 H??lix-Nielsen, Claus Biomimetic Membranes for Sensor and Separation Applications I07555 2012 eBook  
23 Glaser, Roland Biophysics I07449 2012 eBook  
24 Amils, Ricardo Encyclopedia of Astrobiology I07242 2011 eBook  
25 Kuzmany, Hans Solid-State Spectroscopy I07192 2009 eBook  
26 Beckerman, Martin Cellular Signaling in Health and Disease I06893 2009 eBook  
27 Williams, Mark C Biophysics of DNA-Protein Interactions I06889 2011 eBook  
28 Botta, Oliver Strategies of Life Detection I06862 2008 eBook  
29 Noy, Aleksandr Handbook of Molecular Force Spectroscopy I06804 2008 eBook  
30 Koonin, Eugene V Power Laws, Scale-Free Networks and Genome Biology I06757 2006 eBook  
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21.    
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TitleProtein-Nanoparticle Interactions : The Bio-Nano Interface
Author(s)Rahman, Masoud;Laurent, Sophie;Tawil, Nancy;Yahia, L'Hocine;Mahmoudi, Morteza
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2013.
DescriptionX, 86 p : online resource
Abstract NoteIn recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a ???biological identity??? to their surfaces (referred to as a ???corona???), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called ???bio-nano interface,??? has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts
ISBN,Price9783642375552
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. EBOOK 7. EBOOK - SPRINGER 8. Nanoscale science 9. Nanoscale Science and Technology 10. NANOSCIENCE 11. Nanostructures 12. NANOTECHNOLOGY 13. PHARMACOLOGY 14. Pharmacology/Toxicology 15. Protein-Ligand Interactions 16. Proteins??
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22.     
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TitleBiomimetic Membranes for Sensor and Separation Applications
Author(s)H??lix-Nielsen, Claus
PublicationDordrecht, Springer Netherlands, 2012.
DescriptionXVI, 292 p : online resource
Abstract NoteThis book addresses the possibilities and challenges in mimicking biological membranes and creating membrane-based sensor and separation devices. It covers recent advances in developing biomimetic membranes for technological applications with a focus on the use of integral membrane protein mediated transport. It describes the fundamentals of biosensing as well as separation and shows how the two processes??work together in biological systems. The book provides an overview of the current state of the art, points to areas that need further investigation and anticipates future directions in the field. Biomimetics is a truly cross-disciplinary approach and this is exemplified by the challenges in mimicking osmotic processes as they occur in nature using aquaporin protein water channels as central building blocks. In the development of a biomimetic sensor/separation technology, both channel and carrier proteins are important and examples of how these may be reconstituted and controlled in biomimetic membranes are presented. Also new developments in our understanding of the reciprocal coupling between the material properties of the biomimetic matrix and the embedded proteins are discussed.?? The basic concepts of membrane barrier properties are introduced and discussed in terms of lipid and polymer based membranes. Once a given protein is reconstituted in its final host biomimetic matrix, its stability needs to be maintained and controlled and the challenges associated with insertion and stabilization of alpha-helical bundle proteins are exemplified with aquaporin and ion channels as well as sodium-potassium ATPase proteins. The concept of multi-scale modeling is introduced and exemplified by the use of molecular dynamics, dissipative particle dynamics, and computational fluid dynamics simulations illustrating the issues involved in developing and describing biomimetic systems in a wide range of time and length scales. Scalability is a general issue for all nano-inspired technology developments and many biomimetic membrane applications require that the device can be used in the macroscopic realm. This challenge is addressed here in the context of fabricating biomimetic components, membrane arrays, and compartmentalized systems together with the challenges related to microfluidic design strategies for biomimetic device developments
ISBN,Price9789400721845
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. Biomaterials 6. Biomedical engineering 7. Biomedical Engineering and Bioengineering 8. BIOPHYSICS 9. EBOOK 10. EBOOK - SPRINGER
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23.     
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TitleBiophysics : An Introduction
Author(s)Glaser, Roland
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2012.
DescriptionXX, 407 p. 188 illus., 134 illus. in color : online resource
Abstract NoteBiophysics is the science of physical principles underlying all processes of life, including the dynamics and kinetics of biological systems. This fully revised 2nd English edition is an introductory text that spans all steps of biological organization, from the molecular, to the organism level, as well as influences of environmental factors. In response to the enormous progress recently made, especially in theoretical and molecular biophysics, the author has updated the text, integrating new results and developments concerning protein folding and dynamics, molecular aspects of membrane assembly and transport, noise-enhanced processes, and photo-biophysics. The advances made in theoretical biology in the last decade call for a fully new conception of the corresponding sections. Thus, the book provides the background needed for fundamental training in biophysics and, in addition, offers a great deal of advanced biophysical knowledge
ISBN,Price9783642252129
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. CELL BIOLOGY 7. EBOOK 8. EBOOK - SPRINGER 9. Effects of Radiation/Radiation Protection 10. Human physiology 11. Radiation protection 12. Radiation???Safety measures
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24.     
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TitleEncyclopedia of Astrobiology
Author(s)Amils, Ricardo;Cernicharo Quintanilla, Jos??;Cleaves, Henderson James;Irvine, William M;Pinti, Daniele;Viso, Michel
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2011.
DescriptioneReference : online resource
Abstract NoteThe interdisciplinary field of Astrobiology constitutes a joint arena where provocative discoveries are coalescing concerning, e.g. the prevalence of exoplanets, the diversity and hardiness of life, and its increasingly likely chances for its emergence. Biologists, astrophysicists, biochemists, geoscientists and space scientists share this exciting mission of revealing the origin and commonality of life in the Universe. The members of the different disciplines are used to their own terminology and technical language. In the interdisciplinary environment many terms either have redundant meanings or are completely unfamiliar to members of other disciplines. The Encyclopedia of Astrobiology serves as the key to a common understanding. Each new or experienced researcher and graduate student in adjacent fields of astrobiology will appreciate this reference work in the quest to understand the big picture. The carefully selected group of active researchers contributing to this work and the expert field editors intend for their contributions, from an internationally comprehensive perspective, to accelerate the interdisciplinary advance of astrobiology
ISBN,Price9783642112744
Keyword(s)1. ASTROBIOLOGY 2. ASTROPHYSICS 3. Astrophysics and Astroparticles 4. BIOCHEMISTRY 5. Biochemistry, general 6. Biogeosciences 7. Bioorganic Chemistry 8. EBOOK 9. EBOOK - SPRINGER 10. Geobiology 11. PLANETOLOGY
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25.     
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TitleSolid-State Spectroscopy : An Introduction
Author(s)Kuzmany, Hans
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2009.
DescriptionXX, 554 p : online resource
Abstract NoteSpectroscopic methods have opened up a new horizon in our knowledge of solid-state materials. Numerous techniques using electromagnetic radiation or charged and neutral particles have been invented and worked out to a high level in order to provide more detailed information on the solids. The text presented here is an updated description of such methods as they were originally presented in the first edition. It covers linear response of solids to electromagnetic radiation in a frequency range extending from megahertz or gigahertz as used in spin resonance spectroscopy, to infrared spectroscopy and various forms of spectroscopy in the visible and near visible spectral range. It extends to spectroscopy in the UV and x-ray spectral range and eventually several spectroscopic methods are addressed in the frequency range of g radiation. Likewise linear response to irradiation with particles such as electrons, positrons, muons, neutrons, and atoms is discussed. Instrumental and technical background is provided as well as application to the analysis of the solid state. New developments especially addressed in this second edition cover the exciting new field of mesoscopic and nanoscopic solids using light scattering from small particles, single electron (addition) spectroscopy, and quantization in magnetic fields. Likewise, the development and application of synchrotron radiation has encountered a dramatic progress particularly in the field of high resolution and angular resolved photoelectron spectroscopy. Free electron lasers from undulators in linear accelerators are becoming available with dramatic enhancement in brightness and provide a fourth generation of synchrotron light sources. The better understanding and the possibilities to manipulate spin states as it happens in spintronic research stimulated sophisticated technologies in electron and nuclear spin resonance which are also covered in the new edition. Breakthrough developments were obtained in the field of light emission from semiconductor devices and for femtosecond spectroscopy. In addition in almost all other spectroscopic techniques progress was obtained in the last years and is reviewed in the text. Thus the book may be considered as a state-of-the-art introductory text in solid-state spectroscopy. Each chapter includes problems. The concept of this textbook is designed for graduate students and young professors who want to set up lectures or courses in solid-state spectroscopy
ISBN,Price9783642014796
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. CLASSICAL ELECTRODYNAMICS 7. EBOOK 8. EBOOK - SPRINGER 9. ELECTRODYNAMICS 10. LASERS 11. MICROSCOPY 12. OPTICS 13. Optics, Lasers, Photonics, Optical Devices 14. PHOTONICS 15. SOLID STATE PHYSICS 16. SPECTROSCOPY 17. Spectroscopy and Microscopy
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26.     
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TitleCellular Signaling in Health and Disease
Author(s)Beckerman, Martin
PublicationNew York, NY, Springer New York, 2009.
DescriptionXVIII, 470 p. 193 illus : online resource
Abstract NoteIn today???s world, three great classes of non-infectious diseases ??? the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders ??? have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth
ISBN,Price9780387981734
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. Biomedical engineering 6. Biomedical Engineering and Bioengineering 7. BIOPHYSICS 8. CELL BIOLOGY 9. EBOOK 10. EBOOK - SPRINGER 11. Human physiology 12. MOLECULAR BIOLOGY 13. Molecular Medicine
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27.     
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TitleBiophysics of DNA-Protein Interactions : From Single Molecules to Biological Systems
Author(s)Williams, Mark C;Maher, III, L. James
PublicationNew York, NY, Springer New York, 2011.
DescriptionX, 350 p : online resource
Abstract NoteThis book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity
ISBN,Price9780387928081
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. Biomedical engineering 6. Biomedical Engineering and Bioengineering 7. BIOPHYSICS 8. CELL BIOLOGY 9. EBOOK 10. EBOOK - SPRINGER 11. MOLECULAR BIOLOGY 12. Molecular Medicine 13. Protein Structure 14. Proteins??
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28.     
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TitleStrategies of Life Detection
Author(s)Botta, Oliver;Bada, Jeffrey;G??mez Elvira, Javier;Javaux, Emmanuelle;Selsis, Franck;Summons, Robert
PublicationNew York, NY, Springer US, 2008.
DescriptionIV, 382 p : online resource
Abstract NoteThe search for life outside the Earth has been one of mankind's most challenging quests. We have reached a level of technology that allows for initial steps toward thorough scientific investigation. The aim of this workshop was to take an interdisciplinary look at the signatures that would be indicative of past or present life on another planet and compare them to biosignatures on Earth. The purpose of the workshop was also to discuss state-of-the-art in-situ instruments that are envisioned to search for these signatures in the exploration of the solar system, as well as the discussion of concepts descriptive of the search for habitable planets around other stars. This book is intended to provide a reference to scientists and instrument developers working in the field of in-situ and remote life detection. It can also be used as an interdisciplinary introduction for students and post-doctoral researchers entering this new and exciting field
ISBN,Price9780387775166
Keyword(s)1. ASTROBIOLOGY 2. Astronomy, Observations and Techniques 3. Astronomy???Observations 4. ASTROPHYSICS 5. Astrophysics and Astroparticles 6. BIOCHEMISTRY 7. Biochemistry, general 8. EBOOK 9. EBOOK - SPRINGER 10. Observations, Astronomical 11. PLANETOLOGY 12. SPACE SCIENCES 13. Space Sciences (including Extraterrestrial Physics, Space Exploration and Astronautics)
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29.     
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TitleHandbook of Molecular Force Spectroscopy
Author(s)Noy, Aleksandr
PublicationNew York, NY, Springer US, 2008.
DescriptionXII, 300 p. 150 illus : online resource
Abstract Note"...Noy's Handbook of Molecular Force Spectroscopy is both a timely and useful summary of fundamental aspects of molecular force spectroscopy, and I believe it would make a worthwhile addition to any good scientific library. New research groups that are entering this field would be well advisedto study this handbook in detail before venturing into the exciting and challenging world of molecular force spectroscopy." Matthew F. Paige, University of Saskatchewan, Journal of the American Chemical Society Modern materials science and biophysics are increasingly focused on studying and controlling intermolecular interactions on the single-molecule level. Molecular force spectroscopy was developed in the past decade as the result of several unprecedented advances in the capabilities of modern scientific instrumentation, and defines a number of techniques that use mechanical force measurements to study interactions between single molecules and molecular assemblies in chemical and biological systems. Examples of these techniques, which typically target a specific range of experimental systems and geometries, include atomic force microscopy, optical tweezers, surface forces apparatus, and magnetic tweezers. With contributions by internationally renowned scientists, Handbook of Molecular Force Spectroscopy is a comprehensive, state-of-the-art review of modern force spectroscopy, including fundamentals of intermolecular forces, technical aspects of the force measurements, and practical applications. The Handbook presents reviews of fundamental physical concepts of loading single and multiple chemical bonds on the nanometer scale, covers practical aspects of modern single-molecule level techniques, and describes several representative applications of force spectroscopy to the study of chemical and biological processes. Computer modeling of force spectroscopy experiments is addressed as well. In sum, this volume is an authoritative guide to planning, understanding, and analyzing modern molecular force spectroscopy experiments with an emphasis on biophysical research
ISBN,Price9780387499895
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. EBOOK 7. EBOOK - SPRINGER 8. Interfaces (Physical sciences) 9. MICROSCOPY 10. NANOTECHNOLOGY 11. SOLID STATE PHYSICS 12. SPECTROSCOPY 13. Spectroscopy and Microscopy 14. Surface and Interface Science, Thin Films 15. Surfaces (Physics) 16. THIN FILMS
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30.    
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TitlePower Laws, Scale-Free Networks and Genome Biology
Author(s)Koonin, Eugene V;Wolf, Yuri;Karev, Georgy
PublicationNew York, NY, Springer US, 2006.
DescriptionXVI, 258 p : online resource
Abstract NotePower Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena
ISBN,Price9780387339160
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. BIOINFORMATICS 4. Biological and Medical Physics, Biophysics 5. BIOLOGICAL PHYSICS 6. BIOPHYSICS 7. EBOOK 8. EBOOK - SPRINGER 9. Microbial genetics 10. Microbial Genetics and Genomics 11. Microbial genomics 12. PHYSICS 13. Physics, general 14. Proteomics
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