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11 Adeniran, Ismail Modelling the Short QT Syndrome Gene Mutations I07358 2014 eBook  
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TitleModelling the Short QT Syndrome Gene Mutations : And Their Role in Cardiac Arrhythmogenesis
Author(s)Adeniran, Ismail
PublicationCham, Springer International Publishing, 2014.
DescriptionXVII, 217 p. 102 illus., 38 illus. in color : online resource
Abstract NoteThe Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.?? The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as ???outstanding.???
Keyword(s)1. Biological systems 2. CARDIOLOGY 3. Cell membranes?? 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. Membrane Biology 9. Numerical and Computational Physics, Simulation 10. PHYSICS 11. STATISTICAL PHYSICS 12. Statistical Physics and Dynamical Systems 13. Systems biology
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