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21 Oono, Yoshitsugu The Nonlinear World I07377 2013 eBook  
22 Adeniran, Ismail Modelling the Short QT Syndrome Gene Mutations I07358 2014 eBook  
23 Thiriet, Marc Control of Cell Fate in the Circulatory and Ventilatory Systems I07109 2012 eBook  
24 Thiriet, Marc Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems I07055 2013 eBook  
25 Gilbert, Thomas Proceedings of the European Conference on Complex Systems 2012 I06512 2013 eBook  
26 Thiriet, Marc Anatomy and Physiology of the Circulatory and Ventilatory Systems I06388 2014 eBook  
27 Thiriet, Marc Cell and Tissue Organization in the Circulatory and Ventilatory Systems I06270 2011 eBook  
28 Doursat, Ren?? Morphogenetic Engineering I06145 2012 eBook  
29 Thiriet, Marc Signaling at the Cell Surface in the Circulatory and Ventilatory Systems I06089 2012 eBook  
30 Patel, Manish The Role of Model Integration in Complex Systems Modelling I06088 2010 eBook  
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21.    
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TitleThe Nonlinear World : Conceptual Analysis and Phenomenology
Author(s)Oono, Yoshitsugu
PublicationTokyo, Springer Japan, 2013.
DescriptionXII, 300 p : online resource
Abstract NoteThe most important characteristic of the ???world filled with nonlinearity??? is the existence of scale interference: disparate space???time scales interfere with each other. Thus, the effects of unknowable scales invade the world that we can observe directly. This leads to various peculiar phenomena such as chaos, critical phenomena, and complex biological phenomena, among others. Conceptual analysis and phenomenology are the keys to describe and understand phenomena that are subject to scale interference, because precise description of unfamiliar phenomena requires precise concepts and their phenomenological description. The book starts with an illustration of conceptual analysis in terms of chaos and randomness, and goes on to explain renormalization group philosophy as an approach to phenomenology. Then, abduction is outlined as a way to express what we have understood about the world. The book concludes with discussions on how we can approach genuinely complex phenomena, including biological phenomena. The main target of this volume is young people who have just started to appreciate the world seriously. The author also wishes the book to be helpful to those who have been observing the world, but who wish to appreciate it afresh from a different angle
ISBN,Price9784431540298
Keyword(s)1. Applications of Mathematics 2. APPLIED MATHEMATICS 3. COMPLEX SYSTEMS 4. COMPLEXITY 5. COMPUTATIONAL COMPLEXITY 6. DYNAMICAL SYSTEMS 7. DYNAMICS 8. EBOOK 9. EBOOK - SPRINGER 10. ENGINEERING MATHEMATICS 11. STATISTICAL PHYSICS 12. Statistical Physics and Dynamical Systems 13. Systems biology 14. VIBRATION 15. Vibration, Dynamical Systems, Control
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22.     
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TitleModelling the Short QT Syndrome Gene Mutations : And Their Role in Cardiac Arrhythmogenesis
Author(s)Adeniran, Ismail
PublicationCham, Springer International Publishing, 2014.
DescriptionXVII, 217 p. 102 illus., 38 illus. in color : online resource
Abstract NoteThe Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.?? The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as ???outstanding.???
ISBN,Price9783319072005
Keyword(s)1. Biological systems 2. CARDIOLOGY 3. Cell membranes?? 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. Membrane Biology 9. Numerical and Computational Physics, Simulation 10. PHYSICS 11. STATISTICAL PHYSICS 12. Statistical Physics and Dynamical Systems 13. Systems biology
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23.     
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TitleControl of Cell Fate in the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, Springer New York, 2012.
DescriptionX, 538 p : online resource
Abstract NoteThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volumes??1 and 2??are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment.??Volume 1??examined cellular features that allow adaptation to environmental conditions.??Volume 2??begins with a survey of the cell types of the nervous and endocrine systems involved in the regulation of the vasculature and respiratory tract and growth factors.?? It then describes major cell events in the circulatory and ventilatory systems, such as cell growth, proliferation, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered. Describes cell types, functions, and fate in the regulated activities of the circulatory and respiratory systems Presents applications of mechanics and mathematics for an understanding and prediction of function in health and disease Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
ISBN,Price9781461403296
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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24.     
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TitleIntracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, Springer New York, 2013.
DescriptionXV, 1064 p. 31 illus : online resource
Abstract NoteThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.?? Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.?? Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
ISBN,Price9781461443704
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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25.     
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TitleProceedings of the European Conference on Complex Systems 2012
Author(s)Gilbert, Thomas;Kirkilionis, Markus;Nicolis, Gregoire
PublicationCham, Springer International Publishing, 2013.
DescriptionXVII, 1096 p. 316 illus., 219 illus. in color : online resource
Abstract NoteThe European Conference on Complex Systems, held under the patronage of the Complex Systems Society, is an annual event that has become the leading European conference devoted to complexity science. ECCS'12, its ninth edition, took place in Brussels, during the first week of September 2012. It gathered about 650 scholars representing a wide range of topics relating to complex systems research, with emphasis on interdisciplinary approaches. More specifically, the following tracks were covered: ??1. Foundations of Complex Systems 2. Complexity, Information and Computation 3. Prediction, Policy and Planning, Environment 4. Biological Complexity 5. Interacting Populations, Collective Behavior 6. Social Systems, Economics and Finance This book contains a selection of the contributions presented at the conference and its satellite meetings. Its contents reflect the extent, diversity and richness of research areas in the field, both fundamental and applied. ??
ISBN,Price9783319003955
Keyword(s)1. COMPLEX SYSTEMS 2. COMPLEXITY 3. COMPUTATIONAL COMPLEXITY 4. DECISION MAKING 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. OPERATIONS RESEARCH 9. Operations Research/Decision Theory 10. STATISTICAL PHYSICS 11. Statistical Physics and Dynamical Systems 12. Statistics for Social Sciences, Humanities, Law 13. Statistics?? 14. Systems biology
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26.     
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TitleAnatomy and Physiology of the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, Springer New York, 2014.
DescriptionXV, 585 p. 75 illus., 25 illus. in color : online resource
Abstract NoteTogether, the volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to, and remove carbon dioxide from, the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanism. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems, together with the mathematical tools to describe their functioning in quantitative terms. The present volume focuses on macroscopic aspects of the cardiovascular and respiratory systems in normal conditions, i.e., anatomy and physiology, as well as the acquisition and processing of medical images and physiological signals. Reviews the anatomy and physiology of blood circulation and the body's ventilation Reviews biological data for a better understanding of macroscopic scale processes Describes the signals and images that are used to explore system function and as input data for computations
ISBN,Price9781461494690
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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27.     
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TitleCell and Tissue Organization in the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, Springer New York, 2011.
DescriptionXII, 736 p : online resource
Abstract NoteThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. The present volume is devoted to cellular events that allow adaptation to environmental conditions, particularly mechanotransduction. It begins with cell organization and a survey of cell types in the vasculature and respiratory tract. It then addresses cell structure and functions, especially in interactions with adjoining cells and matrix. Describes cell types, functions, and fate in the regulated activities of the circulatory and respiratory systems Presents applications of mechanics and mathematics for an understanding and prediction of function in health and disease Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
ISBN,Price9781441997586
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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28.     
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TitleMorphogenetic Engineering : Toward Programmable Complex Systems
Author(s)Doursat, Ren??;Sayama, Hiroki;Michel, Olivier
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2012.
DescriptionIX, 517 p. 325 illus., 221 illus. in color : online resource
Abstract NoteGenerally, spontaneous pattern formation phenomena are random and repetitive, whereas elaborate devices are the deterministic product of human design. Yet, biological organisms and collective insect constructions are exceptional examples of complex systems that are both self-organized and architectural. ?? This book is the first initiative of its kind toward establishing a new field of research, Morphogenetic Engineering, to explore the modeling and implementation of ???self-architecturing??? systems. Particular emphasis is placed on the programmability and computational abilities of self-organization, properties that are often underappreciated in complex systems science???while, conversely, the benefits of self-organization are often underappreciated in engineering methodologies. ?? Altogether, the aim of this work is to provide a framework for and examples of a larger class of ???self-architecturing??? systems, while addressing fundamental questions such as ?? > How do biological organisms carry out morphogenetic tasks so reliably? > Can we extrapolate their self-formation capabilities to engineered systems? > Can physical systems be endowed with information (or informational systems be embedded in physics) so as to create autonomous morphologies and functions? > What are the core principles and best practices for the design and engineering of such morphogenetic systems? The intended audience consists of researchers and graduate students who are working on, starting to work on, or interested in programmable self-organizing systems in a wide range of scientific fields, including computer science, robotics, bioengineering, control engineering, physics, theoretical biology, mathematics, and many others
ISBN,Price9783642339028
Keyword(s)1. ARTIFICIAL INTELLIGENCE 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. COMPLEX SYSTEMS 6. Computational Intelligence 7. DYNAMICAL SYSTEMS 8. EBOOK 9. EBOOK - SPRINGER 10. STATISTICAL PHYSICS 11. Statistical Physics and Dynamical Systems 12. Systems biology
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29.     
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TitleSignaling at the Cell Surface in the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, Springer New York, 2012.
DescriptionXV, 982 p : online resource
Abstract NoteThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
ISBN,Price9781461419914
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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30.    
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TitleThe Role of Model Integration in Complex Systems Modelling : An Example from Cancer Biology
Author(s)Patel, Manish;Nagl, Sylvia
PublicationBerlin, Heidelberg, Springer Berlin Heidelberg, 2010.
DescriptionX, 168 p : online resource
Abstract NoteModel integration ??? the process by which different modelling efforts can be brought together to simulate the target system ??? is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value
ISBN,Price9783642156038
Keyword(s)1. Cancer Research 2. COMPLEX SYSTEMS 3. COMPLEXITY 4. COMPUTATIONAL COMPLEXITY 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. STATISTICAL PHYSICS 9. Statistical Physics and Dynamical Systems 10. Systems biology
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