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1 Tinker-Mill, Claire Louisa Nanoscale Imaging and Characterisation of Amyloid-?? I10361 2016 eBook  
2 Fern??ndez, Ariel Physics at the Biomolecular Interface I09945 2016 eBook  
3 Tuchin, Valery V Handbook of Coherent-Domain Optical Methods I08429 2013 eBook  
4 Collins, Michael W Micro and Nano Flow Systems for Bioanalysis I08182 2013 eBook  
5 Walter, Nils Non-Protein Coding RNAs I07807 2009 eBook  
6 Nolte, David D Optical Interferometry for Biology and Medicine I07252 2012 eBook  
7 Monastyrsky, Michael I Topology in Molecular Biology I07156 2007 eBook  
8 Beckerman, Martin Cellular Signaling in Health and Disease I06893 2009 eBook  
9 Williams, Mark C Biophysics of DNA-Protein Interactions I06889 2011 eBook  
10 Hinterdorfer, Peter Handbook of Single-Molecule Biophysics I06854 2009 eBook  
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TitleNanoscale Imaging and Characterisation of Amyloid-??
Author(s)Tinker-Mill, Claire Louisa
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2016.
DescriptionXX, 149 p. 59 illus., 14 illus. in color : online resource
Abstract NoteThis thesis presents a method for reliably and robustly producing samples of amyloid-?? (A??) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide???s nanomechanical, elastic, thermal or spectroscopical properties. Amyloid-?? (A??) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of A?? with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes
ISBN,Price9783319395340
Keyword(s)1. Amorphous substances 2. Complex fluids 3. EBOOK 4. EBOOK - SPRINGER 5. MICROSCOPY 6. MOLECULAR BIOLOGY 7. Molecular Medicine 8. NANOTECHNOLOGY 9. Neurology 10. Neurology?? 11. Soft and Granular Matter, Complex Fluids and Microfluidics 12. SPECTROSCOPY 13. Spectroscopy and Microscopy
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TitlePhysics at the Biomolecular Interface : Fundamentals for Molecular Targeted Therapy
Author(s)Fern??ndez, Ariel
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2016.
DescriptionXV, 483 p. 295 illus., 208 illus. in color : online resource
Abstract NoteThis book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines
ISBN,Price9783319308524
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. MOLECULAR BIOLOGY 9. Molecular Medicine 10. Pharmaceutical Sciences/Technology 11. Pharmaceutical technology 12. PHYSICAL CHEMISTRY 13. Protein Structure 14. Proteins?? 15. STATISTICAL PHYSICS
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TitleHandbook of Coherent-Domain Optical Methods : Biomedical Diagnostics, Environmental Monitoring, and Materials Science
Author(s)Tuchin, Valery V
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2013.
Description723 illus., 209 illus. in color. eReference : online resource
Abstract NoteThis Handbook provides comprehensive coverage of laser and coherent-domain methods as applied to biomedicine, environmental monitoring, and materials science. Worldwide leaders in these fields describe the fundamentals of light interaction with random media and present an overview of basic research. The latest results on coherent and polarization properties of light scattered by random media, including tissues and blood, speckles formation in multiple scattering media, and other non-destructive interactions of coherent light with rough surfaces and tissues, allow the reader to understand the principles and applications of coherent diagnostic techniques. The expanded second edition has been thoroughly updated with particular emphasis on novel coherent-domain techniques and their applications in medicine and environmental science. Volume 1 describes state-of-the-art methods of coherent and polarization optical imaging, tomography and spectroscopy; diffusion wave spectroscopy; elastic, quasi-elastic and inelastic light scattering spectroscopy and imaging; digital holographic microscopy, the Fourier transform light scattering method, and coherent diffractive imaging; wavefront sensing, aberration measurement and adaptive optics for ophthalmology; and laser remote sensing. Volume 2 presents the new and growing field of coherent optics in optical coherence tomography (OCT). Various applications of OCT and confocal microscopy, including biomedical endoscopy, are discussed. A special section covers Mueller matrix polarimetry, nonlinear laser fluorescence spectroscopy, and triplet-triplet annihilation assisted upconversion as optical tools for probing the physical parameters of materials and natural organic compounds. Represents the only reference work offering integrated coverage of coherent-domain optical methods for a wide range of applications involving strong light scattering Covers the fundamentals of light interaction with random media Describes specific interactions of coherent and low-coherent light with tissues and blood Presents advanced optical coherence tomography techniques and other non-destructive diagnostic methods Extensively revised and updated from the 2004 edition
ISBN,Price9781461451761
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. Characterization and Evaluation of Materials 7. EBOOK 8. EBOOK - SPRINGER 9. Environmental monitoring 10. MATERIALS SCIENCE 11. MOLECULAR BIOLOGY 12. Molecular Medicine 13. Monitoring/Environmental Analysis 14. SPECTROSCOPY 15. Spectroscopy/Spectrometry
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TitleMicro and Nano Flow Systems for Bioanalysis
Author(s)Collins, Michael W;Koenig, Carola S
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2013.
DescriptionXIV, 214 p : online resource
Abstract NoteMicro and Nano Flow Systems for Bioanalysis addresses the latest developments in biomedical engineering at very small scales. It shows how organic systems require multi-scale understanding in the broadest sense whether the approach?? is experimental or mathematical, and whether the physiological state is healthy or diseased. Micro-and nano-fluidics represent ??key areas of translational research in which state-of-the-art engineering processes and devices are applied to bedside monitoring and treatment. By applying conventional micro- and nano-engineering to complex organic solids, fluids, and their interactions, leading researchers from throughout the world describe methods and techniques with great potential for use in medicine and clinical practice. Coverage includes the seeming plethora of new, fine-scale optical methods for measuring blood flow as well as endothelial activation and interaction with tissue. Generic areas of modeling and bioelectronics are also considered. In keeping with the recurring theme of medicine and clinical practice, approximately half of the chapters focus on the specific application of micro- and nano- flow systems to the understanding and treatment of cancer and cardiovascular diseases. This book developed from an Expert Overview Session on "Micro & Nano Flows in Medicine: the way ahead" at the 3rd Micro and Nano Flows Conference (MNF2011) held in Thessaloniki, Greece. ??Additional chapters were included to enhance the international, state-of-the-art coverage. Covers a broad range of topics, including ultrascale optical measurement methods and the modeling of multiscale biomedical flows Explains the underlying biology in areas such as cascades of reacting agents Includes applications to cardiology and to the detection and treatment of cancer Provides an overview suitable for a broad audience of bioengineering researchers, students, and clinicians
ISBN,Price9781461443766
Keyword(s)1. Amorphous substances 2. Biomedical engineering 3. Biomedical Engineering and Bioengineering 4. Complex fluids 5. EBOOK 6. EBOOK - SPRINGER 7. Engineering Fluid Dynamics 8. FLUID MECHANICS 9. Medical and Radiation Physics 10. Medical physics 11. MOLECULAR BIOLOGY 12. Molecular Medicine 13. NANOTECHNOLOGY 14. Nanotechnology and Microengineering 15. RADIATION 16. Soft and Granular Matter, Complex Fluids and Microfluidics
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TitleNon-Protein Coding RNAs
Author(s)Walter, Nils;Woodson, Sarah A;Batey, Robert T
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2009.
DescriptionXI, 398 p : online resource
Abstract NoteThis book assembles chapters from experts in the Biophysics of RNA to provide a broadly accessible snapshot of the current status of this rapidly expanding field. The 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, highlighting just one example of a large number of non-protein coding RNAs. Because non-protein coding RNAs outnumber protein coding genes in mammals and other higher eukaryotes, it is now thought that the complexity of organisms is correlated with the fraction of their genome that encodes non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic transposons, higher-level organization of eukaryotic chromosomes, and gene expression itself are found to largely be directed by non-protein coding RNAs. The biophysical study of these RNAs employs X-ray crystallography, NMR, ensemble and single molecule fluorescence spectroscopy, optical tweezers, cryo-electron microscopy, and other quantitative tools. This emerging field has begun to unravel the molecular underpinnings of how RNAs fulfill their multitude of roles in sustaining cellular life. The physical and chemical understanding of RNA biology that results from biophysical studies is critical to our ability to harness RNAs for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry
ISBN,Price9783540708407
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. BIOINFORMATICS 4. Biological and Medical Physics, Biophysics 5. BIOLOGICAL PHYSICS 6. BIOPHYSICS 7. CELL BIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Human physiology 11. MOLECULAR BIOLOGY 12. Molecular Medicine
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TitleOptical Interferometry for Biology and Medicine
Author(s)Nolte, David D
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2012.
DescriptionXII, 354 p. 209 illus., 118 illus. in color : online resource
Abstract NoteThis book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and??then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds. Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). An outstanding feature of the book is the clear presentation of the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions. Presents the fundamental physics underlying many biophotonic applications Reviews??the state-of-the-art of interferometric techniques in biology and medicine Serves as a??mathematical reference with complete derivations of results Includes numerous graphs and figures to help illustrate interference phenomena
ISBN,Price9781461408901
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. EBOOK 7. EBOOK - SPRINGER 8. LASERS 9. MOLECULAR BIOLOGY 10. Molecular Medicine 11. Optics, Lasers, Photonics, Optical Devices 12. PHOTONICS
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TitleTopology in Molecular Biology
Author(s)Monastyrsky, Michael I
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2007.
DescriptionXIV, 238 p. 118 illus., 6 illus. in color : online resource
Abstract NoteThe book presents a class of new results in molecular biology for which topological methods and ideas are important. These include: the large-scale conformation properties of DNA; computational methods (Monte Carlo) allowing the simulation of large-scale properties of DNA; the tangle model of DNA recombination and other applications of Knot theory; dynamics of supercoiled DNA and biocatalitic properties of DNA; the structure of proteins; and other very recent problems in molecular biology. The text also provides a short course of modern topology intended for the broad audience of biologists and physicists. The authors are renowned specialists in their fields and some of the new results presented here are documented for the first time in monographic form
ISBN,Price9783540498582
Keyword(s)1. BIOINFORMATICS 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. EBOOK 6. EBOOK - SPRINGER 7. MOLECULAR BIOLOGY 8. Molecular Medicine
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TitleCellular Signaling in Health and Disease
Author(s)Beckerman, Martin
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2009.
DescriptionXVIII, 470 p. 193 illus : online resource
Abstract NoteIn today???s world, three great classes of non-infectious diseases ??? the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders ??? have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth
ISBN,Price9780387981734
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. Biomedical engineering 6. Biomedical Engineering and Bioengineering 7. BIOPHYSICS 8. CELL BIOLOGY 9. EBOOK 10. EBOOK - SPRINGER 11. Human physiology 12. MOLECULAR BIOLOGY 13. Molecular Medicine
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TitleBiophysics of DNA-Protein Interactions : From Single Molecules to Biological Systems
Author(s)Williams, Mark C;Maher, III, L. James
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2011.
DescriptionX, 350 p : online resource
Abstract NoteThis book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity
ISBN,Price9780387928081
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. Biomedical engineering 6. Biomedical Engineering and Bioengineering 7. BIOPHYSICS 8. CELL BIOLOGY 9. EBOOK 10. EBOOK - SPRINGER 11. MOLECULAR BIOLOGY 12. Molecular Medicine 13. Protein Structure 14. Proteins??
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TitleHandbook of Single-Molecule Biophysics
Author(s)Hinterdorfer, Peter;van Oijen, Antoine
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2009.
DescriptionXXI, 626 p : online resource
Abstract NoteThe last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level of sensitivity has given rise to an improved understanding of the underlying molecular mechanisms. Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transient intermediates identified, and catalytic mechanisms elucidated. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook of Single-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them. Coverage includes: Experimental techniques to monitor and manipulate individual biomolecules The use of single-molecule techniques in super-resolution and functional imaging Single-molecule studies of physical properties of biomolecules Single-molecule enzymology and biochemistry Single molecules in the membrane Single-molecule techniques in living cells Integration of single-molecule biophysics and nanoscience
ISBN,Price9780387764979
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. EBOOK 7. EBOOK - SPRINGER 8. LASERS 9. LIFE SCIENCES 10. Life Sciences, general 11. MOLECULAR BIOLOGY 12. Molecular Medicine 13. NANOTECHNOLOGY 14. Optics, Lasers, Photonics, Optical Devices 15. PHOTONICS
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