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Author | Title | Accn# | Year | Item Type | Claims |
| 1 |
Beckerman, Martin |
Cellular Signaling in Health and Disease |
I06893 |
2009 |
eBook |
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| 2 |
Beckerman, Martin |
Molecular and Cellular Signaling |
I05387 |
2005 |
eBook |
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1.
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| Title | Cellular Signaling in Health and Disease |
| Author(s) | Beckerman, Martin |
| Publication | New York, NY, Springer New York, 2009. |
| Description | XVIII, 470 p. 193 illus : online resource |
| Abstract Note | In today???s world, three great classes of non-infectious diseases ??? the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders ??? have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth |
| ISBN,Price | 9780387981734 |
| Keyword(s) | 1. BIOCHEMISTRY
2. Biochemistry, general
3. Biological and Medical Physics, Biophysics
4. BIOLOGICAL PHYSICS
5. Biomedical engineering
6. Biomedical Engineering and Bioengineering
7. BIOPHYSICS
8. CELL BIOLOGY
9. EBOOK
10. EBOOK - SPRINGER
11. Human physiology
12. MOLECULAR BIOLOGY
13. Molecular Medicine
|
| Item Type | eBook |
Multi-Media Links
Please Click here for eBook
Circulation Data
| Accession# | |
Call# | Status | Issued To | Return Due On | Physical Location |
| I06893 |
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On Shelf |
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2.
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| Title | Molecular and Cellular Signaling |
| Author(s) | Beckerman, Martin |
| Publication | New York, NY, Springer New York, 2005. |
| Description | XXXIV, 582 p. 227 illus : online resource |
| Abstract Note | A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding. About the Author: Martin Beckerman, Ph.D. is Senior Scientist at the Center forMartin Beckerman, PhD, is a senior research scientist at the Department of Energy/National Nuclear Security Administration???s Y-12 National Security Complex in Oak Ridge, TN. Prior to assuming his current position at the Y-12 NSC, Dr. Beckerman held teaching and research positions at the Weizmann Institute of Science, the University of Rochester, the Massachusetts Institute of Technology, the University of Tennessee and the Oak Ridge National Laboratory. He has authored over 130 publications and has been included in 1400 citations |
| ISBN,Price | 9780387260150 |
| Keyword(s) | 1. BIOCHEMISTRY
2. Biochemistry, general
3. Biological and Medical Physics, Biophysics
4. BIOLOGICAL PHYSICS
5. Biomedical engineering
6. Biomedical Engineering and Bioengineering
7. BIOPHYSICS
8. CELL BIOLOGY
9. EBOOK
10. EBOOK - SPRINGER
11. MOLECULAR BIOLOGY
12. Molecular Medicine
|
| Item Type | eBook |
Multi-Media Links
Please Click here for eBook
Circulation Data
| Accession# | |
Call# | Status | Issued To | Return Due On | Physical Location |
| I05387 |
|
|
On Shelf |
|
|
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