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Author | Title | Accn# | Year | Item Type | Claims |
| 1 |
Waters, Michael |
Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II |
I03912 |
1980 |
eBook |
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| 2 |
Waters, Michael |
Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV |
I03288 |
1985 |
eBook |
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| Title | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II |
| Author(s) | Waters, Michael;Nesnow, Stephen;Huisingh, Joellen L;Sandhu, Shahbeg S;Claxton, Larry |
| Publication | New York, NY, Springer US, 1980. |
| Description | 524 p. 40 illus : online resource |
| Abstract Note | More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing |
| ISBN,Price | 9781468441215 |
| Keyword(s) | 1. EBOOK
2. EBOOK - SPRINGER
3. PHYSICS
4. Physics, general
|
| Item Type | eBook |
Multi-Media Links
Please Click here for eBook
Circulation Data
| Accession# | |
Call# | Status | Issued To | Return Due On | Physical Location |
| I03912 |
|
|
On Shelf |
|
|
|
|
2.
 | |
| Title | Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV |
| Author(s) | Waters, Michael |
| Publication | New York, NY, Springer US, 1985. |
| Description | X, 384 p. 32 illus : online resource |
| Abstract Note | With this proceedings of the fourth symposium on complex mixtures, we continue to revise and extend our knowledge of genetic methods for the evaluation of chemical mixtures in the environment. The early chapters of this volume are devoted to new bioassay techniques that are directly applicable to the monitoring of environments contaminated with genotoxic chemicals. Microbiological methods have been further refined to meet the special needs of atmospheric monitoring so that very small samples may now be efficiently tested. New in situ methods utilizing green plants actually avoid many of the usual difficulties of sample collection and preparation and offer special advantages in monitoring wastewater, sludges, and hazardous wastes. Insects also are being employed very effectively in the evaluation of gaseous air pollutants in controlled laboratory investigations. Increased emphasis has been placed on a comprehensive assessment of the potential of complex mixtures t9 cause various kinds of genetic damage. New assays for chromosome structural and numerical aberrations in mammalian cells in vitro have been developed and are being applied in laboratory studies. Efforts to link tests for gene mutation and cell transformation in vitro with assays for tumorigenesis in vivo are contributing to the validation of the short-term testing approach. Studies comparing in vitro and in vivo data on a coal conversion by-product, on polycyclic aromatic hydrocarbons, and on mineral fibers are reported in separate papers. Later chapters are devoted to investigations on the fractionation and biological evaluation of specific chemical components within complex mixtures |
| ISBN,Price | 9781461578499 |
| Keyword(s) | 1. EBOOK
2. EBOOK - SPRINGER
3. PHYSICS
4. Physics, general
|
| Item Type | eBook |
Multi-Media Links
Please Click here for eBook
Circulation Data
| Accession# | |
Call# | Status | Issued To | Return Due On | Physical Location |
| I03288 |
|
|
On Shelf |
|
|
|
| |