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 #  AuthorTitleAccn#YearItem Type Claims
1 Velmurugu, Yogambigai Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition I10294 2017 eBook  
2 Ashrafuzzaman, Mohammad Membrane Biophysics I08181 2013 eBook  
3 Rahman, Masoud Protein-Nanoparticle Interactions I07681 2013 eBook  
4 Sussman, Joel L From Molecules to Medicines I05408 2009 eBook  
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TitleDynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition
Author(s)Velmurugu, Yogambigai
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2017.
DescriptionXXI, 199 p. 112 illus., 105 illus. in color : online resource
Abstract NoteUsing a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually ???stumbles??? upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.
ISBN,Price9783319451299
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. MICROSCOPY 7. Protein-Ligand Interactions 8. Proteins?? 9. SPECTROSCOPY 10. Spectroscopy and Microscopy
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TitleMembrane Biophysics
Author(s)Ashrafuzzaman, Mohammad;Tuszynski, Jack A
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2013.
DescriptionXIV, 182 p : online resource
Abstract NotePhysics, mathematics and chemistry all play a vital role in understanding the true nature and functioning of biological membranes, key elements of living processes. Besides simple spectroscopic observations and electrical measurements of membranes we address in this book the phenomena of coexistence and independent existence of different membrane components using various theoretical approaches. This treatment will be helpful for readers who want to understand biological processes by applying both simple observations and fundamental scientific analysis. It provides a deep understanding of the causes and effects of processes inside membranes, and will thus eventually open new doors for high-level pharmaceutical approaches towards fighting membrane- and cell-related diseases
ISBN,Price9783642161056
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. Cell membranes?? 5. EBOOK 6. EBOOK - SPRINGER 7. Membrane Biology 8. Nanoscale science 9. Nanoscale Science and Technology 10. NANOSCIENCE 11. Nanostructures 12. Numerical and Computational Physics, Simulation 13. PHYSICAL CHEMISTRY 14. PHYSICS 15. Protein-Ligand Interactions 16. Proteins??
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TitleProtein-Nanoparticle Interactions : The Bio-Nano Interface
Author(s)Rahman, Masoud;Laurent, Sophie;Tawil, Nancy;Yahia, L'Hocine;Mahmoudi, Morteza
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2013.
DescriptionX, 86 p : online resource
Abstract NoteIn recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a ???biological identity??? to their surfaces (referred to as a ???corona???), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called ???bio-nano interface,??? has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts
ISBN,Price9783642375552
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. EBOOK 7. EBOOK - SPRINGER 8. Nanoscale science 9. Nanoscale Science and Technology 10. NANOSCIENCE 11. Nanostructures 12. NANOTECHNOLOGY 13. PHARMACOLOGY 14. Pharmacology/Toxicology 15. Protein-Ligand Interactions 16. Proteins??
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TitleFrom Molecules to Medicines : Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism
Author(s)Sussman, Joel L;Spadon, Paola
PublicationDordrecht, 1. Imprint: Springer 2. Springer Netherlands, 2009.
DescriptionXV, 251 p : online resource
ISBN,Price9789048123391
Keyword(s)1. BIOINFORMATICS 2. COMPUTER SIMULATION 3. CRYSTALLOGRAPHY 4. Crystallography and Scattering Methods 5. EBOOK 6. EBOOK - SPRINGER 7. Protein Structure 8. Protein-Ligand Interactions 9. Proteins?? 10. Simulation and Modeling
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