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 #  AuthorTitleAccn#YearItem Type Claims
1 Karschau, Jens Mathematical Modelling of Chromosome Replication and Replicative Stress I08011 2015 eBook  
2 Garc??a G??mez-Tejedor, Gustavo Radiation Damage in Biomolecular Systems I05428 2012 eBook  
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TitleMathematical Modelling of Chromosome Replication and Replicative Stress
Author(s)Karschau, Jens
PublicationCham, Springer International Publishing, 2015.
DescriptionXIII, 76 p. 57 illus., 9 illus. in color : online resource
Abstract NoteDNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next, and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. ?? This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome; and how is the spatial organization of replication factories achieved inside the nucleus of a cell? ?? A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially??further our understanding of??disease mechanisms??such as the abnormal replication in cancer
ISBN,Price9783319088617
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. Genetic engineering 9. Nucleic Acid Chemistry 10. Nucleic acids 11. Numerical and Computational Physics, Simulation 12. PHYSICS 13. STATISTICAL PHYSICS 14. Statistical Physics and Dynamical Systems
Item TypeeBook
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Accession#  Call#StatusIssued ToReturn Due On Physical Location
I08011     On Shelf    

2.    
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TitleRadiation Damage in Biomolecular Systems
Author(s)Garc??a G??mez-Tejedor, Gustavo;Fuss, Martina Christina
PublicationDordrecht, Springer Netherlands, 2012.
DescriptionXIV, 510 p : online resource
Abstract NoteSince the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can induce molecular fragmentation via dissociative processes such as internal excitation and electron attachment. This prompted collaborative projects between different research groups from European countries together with other specialists from Canada,?? the USA and Australia. This book??summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems. The book will be of interest to researchers and advanced students in the fields of radiation physics, chemistry and radiation therapy
ISBN,Price9789400725645
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. Effects of Radiation/Radiation Protection 7. Medical and Radiation Physics 8. Medical physics 9. Nucleic Acid Chemistry 10. Nucleic acids 11. RADIATION 12. Radiation protection 13. Radiation???Safety measures 14. Radiotherapy
Item TypeeBook
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Accession#  Call#StatusIssued ToReturn Due On Physical Location
I05428     On Shelf    

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