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1 Ashrafuzzaman, Mohammad Membrane Biophysics I08181 2013 eBook  
2 Kr??mer, Reinhard Membrane Transport Mechanism I07955 2014 eBook  
3 Adeniran, Ismail Modelling the Short QT Syndrome Gene Mutations I07358 2014 eBook  
4 Guseva, Ksenia Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane I06092 2012 eBook  
5 Costard, Ren?? Ultrafast Dynamics of Phospholipid-Water Interfaces I05461 2015 eBook  
6 Akabori, Kiyotaka Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering I05456 2015 eBook  
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TitleMembrane Biophysics
Author(s)Ashrafuzzaman, Mohammad;Tuszynski, Jack A
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2013.
DescriptionXIV, 182 p : online resource
Abstract NotePhysics, mathematics and chemistry all play a vital role in understanding the true nature and functioning of biological membranes, key elements of living processes. Besides simple spectroscopic observations and electrical measurements of membranes we address in this book the phenomena of coexistence and independent existence of different membrane components using various theoretical approaches. This treatment will be helpful for readers who want to understand biological processes by applying both simple observations and fundamental scientific analysis. It provides a deep understanding of the causes and effects of processes inside membranes, and will thus eventually open new doors for high-level pharmaceutical approaches towards fighting membrane- and cell-related diseases
ISBN,Price9783642161056
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. Cell membranes?? 5. EBOOK 6. EBOOK - SPRINGER 7. Membrane Biology 8. Nanoscale science 9. Nanoscale Science and Technology 10. NANOSCIENCE 11. Nanostructures 12. Numerical and Computational Physics, Simulation 13. PHYSICAL CHEMISTRY 14. PHYSICS 15. Protein-Ligand Interactions 16. Proteins??
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TitleMembrane Transport Mechanism : 3D Structure and Beyond
Author(s)Kr??mer, Reinhard;Ziegler, Christine
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2014.
DescriptionXII, 272 p. 65 illus., 56 illus. in color : online resource
Abstract NoteThis book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing number of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. ?? The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. ?? This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. ?? The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture, or, more precisely, ???a molecular movie???. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics
ISBN,Price9783642538391
Keyword(s)1. BIOINFORMATICS 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. Cell membranes?? 6. Computational Biology/Bioinformatics 7. CRYSTALLOGRAPHY 8. Crystallography and Scattering Methods 9. EBOOK 10. EBOOK - SPRINGER 11. Membrane Biology 12. Protein Structure 13. Proteins??
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TitleModelling the Short QT Syndrome Gene Mutations : And Their Role in Cardiac Arrhythmogenesis
Author(s)Adeniran, Ismail
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2014.
DescriptionXVII, 217 p. 102 illus., 38 illus. in color : online resource
Abstract NoteThe Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.?? The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as ???outstanding.???
ISBN,Price9783319072005
Keyword(s)1. Biological systems 2. CARDIOLOGY 3. Cell membranes?? 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. Membrane Biology 9. Numerical and Computational Physics, Simulation 10. PHYSICS 11. STATISTICAL PHYSICS 12. Statistical Physics and Dynamical Systems 13. Systems biology
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TitleFormation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
Author(s)Guseva, Ksenia
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2012.
DescriptionXII, 80 p : online resource
Abstract NoteWith the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process
ISBN,Price9783642239885
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. Cell membranes?? 5. COMPLEX SYSTEMS 6. DYNAMICAL SYSTEMS 7. EBOOK 8. EBOOK - SPRINGER 9. Membrane Biology 10. Polymer Sciences 11. Polymers???? 12. STATISTICAL PHYSICS 13. Statistical Physics and Dynamical Systems
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5.     
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TitleUltrafast Dynamics of Phospholipid-Water Interfaces : Studied by Nonlinear Time-Resolved Vibrational Spectroscopy
Author(s)Costard, Ren??
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2015.
DescriptionX, 103 p. 42 illus., 6 illus. in color : online resource
Abstract NoteThis thesis presents a highly innovative study of the ultrafast structural and vibrational dynamics of hydrated phospholipids, the basic constituents of cell membranes. As a novel approach to the water-phospholipid interface, the author studies phosphate vibrations using the most advanced methods of nonlinear vibrational spectroscopy, including femtosecond two-dimensional infrared spectroscopy. He shows for the first time that the structure of interfacial water undergoes very limited fluctuations on a 300 fs time scale and that the lifetimes of hydrogen bonds with the phospholipid are typically longer than 10 ps. Such properties originate from the steric hindrance of water fluctuations at the interface and the orienting action of strong electric fields from the phospholipid head group dipoles. In an extensive series of additional experiments, the vibrational lifetimes of the different vibrations and the processes of energy dissipation are elucidated in detail
ISBN,Price9783319220666
Keyword(s)1. Atomic structure???? 2. Atomic/Molecular Structure and Spectra 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. Cell membranes?? 7. EBOOK 8. EBOOK - SPRINGER 9. Membrane Biology 10. MICROSCOPY 11. Molecular structure?? 12. PHYSICAL CHEMISTRY 13. SPECTROSCOPY 14. Spectroscopy and Microscopy
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TitleStructure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering
Author(s)Akabori, Kiyotaka
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2015.
DescriptionXX, 168 p. 114 illus., 89 illus. in color : online resource
Abstract NoteThis Thesis in biological physics has two components, describing??the use of X-ray scattering techniques??to study the structure of two different stacked lipid membrane systems.?? The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-1 virus.?? Although highly positively charged, the Tat protein has been shown to translocate through hydrocarbon lipid bilayers easily, without requiring the cell???s energy, which is counter to its Born self-energy.?? In this work Tat???s location in the headgroup region was demonstrated using a combined X-ray scattering and molecular dynamics approach.?? Bilayer thinning was observed as well as softening of different membrane mimics due to Tat.?? It was concluded that Tat???s headgroup location, which increases the area/lipid, and its bilayer softening likely reduce the energy barrier for passive translocation. The second part is a rigorous investigation of an enigmatic phase in the phase diagram of the lipid dimyristoylphosphatidylcholine (DMPC).?? The ripple phase has fascinated many researchers in condensed matter physics and physical chemistry as an example of periodically modulated phases, with many theoretical and simulation papers published.?? Despite systematic studies over the past three decades, molecular details of the structure were still lacking.?? By obtaining the highest resolution X-ray data so far, this work revealed the complex nature of the chain packing, as well as confirming that the major side is thicker than the minor side of the saw-tooth ripple structure.?? The new model shows that the chains in the major arm are tilted with respect to the bilayer normal and that the chains in the minor arm are slightly more disordered than all-trans gel-phase chains, i.e., the chains in the minor arm are more fluid-like.?? This work provides the highest resolution X-ray structure of the ripple phase to-date
ISBN,Price9783319222103
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. Cell membranes?? 5. CRYSTALLOGRAPHY 6. Crystallography and Scattering Methods 7. EBOOK 8. EBOOK - SPRINGER 9. Membrane Biology 10. PHYSICAL CHEMISTRY
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