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1 Scherer, Philipp O.J Theoretical Molecular Biophysics I09798 2017 eBook  
2 Popot, Jean-Luc Membrane Proteins in Aqueous Solutions I09698 2018 eBook  
3 Joo, Chirlmin Biophysics of RNA-Protein Interactions I09182 2019 eBook  
4 Likhtenshtein, Gertz I Nitroxides I08904 2020 eBook  
5 Xu, Ying Computational Methods for Protein Structure Prediction and Modeling I06814 2007 eBook  
6 Lever, Greg Large-Scale Quantum-Mechanical Enzymology I06175 2015 eBook  
7 Frauenfelder, Hans The Physics of Proteins I05637 2010 eBook  
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TitleTheoretical Molecular Biophysics
Author(s)Scherer, Philipp O.J;Fischer, Sighart F
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2017.
DescriptionXVI, 513 p. 226 illus., 27 illus. in color : online resource
Abstract NoteThis book gives an introduction to molecular biophysics. It starts from material properties at equilibrium related to polymers, dielectrics and membranes. Electronic spectra are developed for the understanding of elementary dynamic processes in photosynthesis including proton transfer and dynamics of molecular motors. Since the molecular structures of functional groups of bio-systems were resolved, it has become feasible to develop a theory based on the quantum theory and statistical physics with emphasis on the specifics of the high complexity of bio-systems. This introduction to molecular aspects of the field focuses on solvable models. Elementary biological processes provide as special challenge the presence of partial disorder in the structure which does not destroy the basic reproducibility of the processes. Apparently the elementary molecular processes are organized in a way to optimize the efficiency. Learning from nature by means exploring the relation between structure and function may even help to build better artificial solar cells. The reader is exposed to basic concepts in modern biophysics, such as entropic forces, phase separation, potential of mean force, electron and proton transfer, heterogeneous reactions, coherent and incoherent energy transfer as well as molecular motors. Basic knowledge in classical and Quantum mechanics, electrostatics and statistical physics is desirable. Simplified models are presented which can be solved in limited cases analytically from the guiding lines to generate the basis for a fundamental understanding of the more complex biophysical systems. Chapters close with challenging problems whose solutions are provided at the end of the book to complete the pedagogical treatment in the book. To the second edition several new chapters were added. The medium polarization is treated self-consistently using basic elements of polaron theory and more advanced nonlinear Schr??dinger equations to describe the dynamics of solvation. Ion transport through a membrane was extended by the discussion of cooperative effects. Intramolecular transitions are now discussed in the new edition in much more detail, including also radiationless transitions. Very recent developments in spectroscopy are included, especially two-dimensional and hole-burning spectroscopy. The discussion of charge transfer processes was extended by including recent results of hole transfer in DNA in connection with the super-exchange mechanism. The chapter on molecular motors was rewritten to include the most recent developments of new models. The book is a useful text for students and researchers wanting to go through the mathematical derivations in the theories presented. This book attracts a group of applied mathematically oriented students and scholars to the exciting field of molecular biophysics.??
ISBN,Price9783662556719
Keyword(s)1. Biochemical engineering 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOMATHEMATICS 5. Biomedical engineering 6. Biomedical Engineering and Bioengineering 7. BIOPHYSICS 8. EBOOK 9. EBOOK - SPRINGER 10. Mathematical and Computational Biology 11. Protein Science 12. Proteins??
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2.     
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TitleMembrane Proteins in Aqueous Solutions : From Detergents to Amphipols
Author(s)Popot, Jean-Luc
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2018.
DescriptionXXVII, 708 p. 437 illus., 266 illus. in color : online resource
Abstract NoteMembrane proteins represent about one third of the proteins encoded in a cell's genome, and, because of their key physiological roles, more than half of drug targets. Detergents are traditionally used to extract proteins from membranes in order to make them amenable to the tools of biochemistry and biophysics. However, detergent-solubilized proteins are generally unstable. This has led to the development of alternative, non-conventional surfactants, such as bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants, and specially designed amphipathic polymers called 'amphipols'. These novel tools, mainly developed over the past 20 years, are revolutionizing handling membrane proteins in vitro for basic and applied research, as well as for such biomedical applications as drug screening or vaccination. This book, written by a specialist of membrane proteins and one of the creators of amphipols, describes the properties and uses of these novel molecules. It opens with general introductions on membrane proteins and their natural environment, detergents, the current status of membrane protein in vitro studies, a broad panorama of non-conventional surfactants and a discussion of their respective advantages and limitations, and the preparation and properties of amphipols and membrane protein/amphipol complexes. Topical chapters cover in vitro folding, cell-free synthesis and stabilization of membrane proteins, and such biophysical and biochemical applications as electron microscopy, Xray diffraction, NMR, optical spectroscopy, mass spectrometry, the whole range of solutions studies, proteomics, and such practical applications as membrane protein immobilization and drug screening and the use of amphipols in vivo for vaccination and drug delivery. Each topical chapter is introduced with a concise, up-to-date overview of how membrane proteins are currently studied using each individual technique, before offering an exhaustive coverage and in-depth discussion of the contribution of amphipols, and concluding with hands-on protocols written by everyday practitioners of each application. In addition to a comprehensive coverage of the properties and uses of non-conventional surfactants, this book therefore also offers a concise, accessible introduction to membrane protein biochemistry and biophysics. It is meant to be used both in basic and applied research laboratories and as a teaching help
ISBN,Price9783319731483
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. Medicinal chemistry 7. Pharmaceutical Sciences/Technology 8. Pharmaceutical technology 9. PHYSICAL CHEMISTRY 10. Polymer Sciences 11. Polymers???? 12. Protein Science 13. Proteins??
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TitleBiophysics of RNA-Protein Interactions : A Mechanistic View
Author(s)Joo, Chirlmin;Rueda, David
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2019.
DescriptionVII, 249 p. 77 illus., 74 illus. in color : online resource
Abstract NoteRNA molecules play key roles in all aspects of cellular life, but to do so efficiently, they must work in synergism with proteins. This book addresses how proteins and RNA interact to carry out biological functions such as protein synthesis, regulation of gene expression, genome defense, liquid phase separation and more. The topics addressed in this volume will appeal to researchers in biophysics, biochemistry and structural biology. The book is a useful resource for anybody interested in elucidating the molecular mechanisms and discrete properties of RNA-protein complexes. Included are reviews of key systems such as microRNA and CRISPR/Cas that exemplify how RNA and proteins work together to perform their biological function. Also covered are techniques ranging from single molecule fluorescence and force spectroscopy to crystallography, cryo-EM microscopy, and kinetic modeling
ISBN,Price9781493997268
Keyword(s)1. Analytical chemistry 2. Biochemical engineering 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. BIOPHYSICS 6. EBOOK 7. EBOOK - SPRINGER 8. Protein Science 9. Proteins??
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4.     
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TitleNitroxides : Brief History, Fundamentals, and Recent Developments
Author(s)Likhtenshtein, Gertz I
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2020.
DescriptionXI, 316 p : online resource
Abstract NoteWritten by a pioneer in the development of spin labeling in biophysics, this expert book covers the fundamentals of nitroxide spin labeling through cutting-edge applications in chemistry, physics, materials science, molecular biology, and biomedicine. Nitroxides have earned their place as one of the most popular organic paramagnets due to their suitability as inhibitors of oxidative processes, as a means to polarize magnetic nuclei, and, in molecular biology, as probes and labels to understand molecular structures and dynamics as drags for cancer and other diseases. Beginning with an overview of the basic methodology and nitroxides??? 145-year history, this book equips students with necessary background and techniques to undertake original research and industry work in this growing field
ISBN,Price9783030348229
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. Electronic materials 7. MAGNETIC MATERIALS 8. MAGNETISM 9. Magnetism, Magnetic Materials 10. Optical and Electronic Materials 11. OPTICAL MATERIALS 12. Pharmaceutical Sciences/Technology 13. Pharmaceutical technology 14. Polymer Sciences 15. Polymers???? 16. Protein Science 17. Proteins??
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5.     
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TitleComputational Methods for Protein Structure Prediction and Modeling : Volume 1: Basic Characterization
Author(s)Xu, Ying;Xu, Dong;Liang, Jie
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2007.
DescriptionXX, 396 p. 88 illus : online resource
Abstract NoteVolume one of this two volume sequence focuses on the basic characterization of known protein structures as well as structure prediction from protein sequence information. The 11 chapters provide an overview of the field, covering key topics in modeling, force fields, classification, computational methods, and struture prediction. Each chapter is a self contained review designed to cover (1) definition of the problem and an historical perspective, (2) mathematical or computational formulation of the problem, (3) computational methods and algorithms, (4) performance results, (5) existing software packages, and (6) strengths, pitfalls, challenges, and future research directions
ISBN,Price9780387683720
Keyword(s)1. BIOINFORMATICS 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. EBOOK 6. EBOOK - SPRINGER 7. Protein Science 8. Proteins?? 9. Proteomics
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6.     
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TitleLarge-Scale Quantum-Mechanical Enzymology
Author(s)Lever, Greg
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2015.
DescriptionXVII, 148 p. 30 illus., 12 illus. in color : online resource
Abstract NoteThis work??establishes linear-scaling density-functional theory?? (DFT) as a powerful tool for understanding enzyme catalysis,??one that can complement quantum mechanics/molecular mechanics (QM/MM)??and molecular dynamics??simulations. The thesis reviews benchmark studies demonstrating techniques capable of simulating entire enzymes at the ab initio quantum-mechanical level of accuracy. DFT has transformed the physical sciences by allowing researchers to perform parameter-free quantum-mechanical calculations to predict a broad range of physical and chemical properties of materials. In principle, similar methods could be applied to biological problems. However, even the simplest biological systems contain many thousands of atoms and are characterized by extremely complex configuration spaces associated with a vast number of degrees of freedom. The development of linear-scaling density-functional codes makes biological molecules accessible to quantum-mechanical calculation, but has yet to resolve the complexity of the phase space. Furthermore, these calculations on systems containing up to 2,000 atoms can capture contributions to the energy that are not accounted for in QM/MM methods (for which the Nobel prize in Chemistry was awarded in 2013), and the results presented here reveal profound shortcomings in said methods
ISBN,Price9783319193519
Keyword(s)1. BIOINFORMATICS 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. Computational Biology/Bioinformatics 6. EBOOK 7. EBOOK - SPRINGER 8. Enzymology 9. PHYSICAL CHEMISTRY 10. Protein Science 11. Proteins??
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7.    
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TitleThe Physics of Proteins : An Introduction to Biological Physics and Molecular Biophysics
Author(s)Frauenfelder, Hans;Chan, Shirley S;Chan, Winnie S
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2010.
DescriptionXVI, 448 p. 221 illus., 7 illus. in color : online resource
Abstract NotePhysics and the life sciences have established new connections within the past few decades, resulting in biological physics as an established subfield with strong groups working in many physics departments. These interactions between physics and biology form a two-way street with physics providing new tools and concepts for understanding life, while biological systems can yield new insights into the physics of complex systems. To address the challenges of this interdisciplinary area, The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics is divided into three interconnected sections. In Parts I and II, early chapters introduce the terminology and describe the main biological systems that physicists will encounter. Similarities between biomolecules, glasses, and solids are stressed with an emphasis on the fundamental concepts of living systems. The central section (Parts III and IV) delves into the dynamics of complex systems. A main theme is the realization that biological systems, in particular proteins, do not exist in unique conformations but can assume a very large number of slightly different structures. This complexity is captured in the concept of a free energy landscape and leads to the conclusion that fluctuations are crucial for the functioning of biological systems. The final chapter of this section challenges the reader to apply these concepts to a problem that appears in the current literature. An extensive series of appendices (Part V) provide descriptions of the key physical tools and analytical methods that have proven powerful in the study of the physics of proteins. The appendices are designed to be consulted throughout the section on protein dynamics without breaking the deductive flow of the logic in the central section of the book
ISBN,Price9781441910448
Keyword(s)1. BIOCHEMISTRY 2. Biochemistry, general 3. Biological and Medical Physics, Biophysics 4. BIOLOGICAL PHYSICS 5. Biomedical engineering 6. Biomedical Engineering and Bioengineering 7. Biomedicine, general 8. BIOPHYSICS 9. EBOOK 10. EBOOK - SPRINGER 11. MEDICINE 12. Protein Science 13. Proteins?? 14. Proteomics
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