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 #  AuthorTitleAccn#YearItem Type Claims
1 Fern??ndez, Ariel Physics at the Biomolecular Interface I09945 2016 eBook  
2 Popot, Jean-Luc Membrane Proteins in Aqueous Solutions I09698 2018 eBook  
3 Likhtenshtein, Gertz I Nitroxides I08904 2020 eBook  
4 Wotring, Virginia E Space Pharmacology I05696 2012 eBook  
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1.    
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TitlePhysics at the Biomolecular Interface : Fundamentals for Molecular Targeted Therapy
Author(s)Fern??ndez, Ariel
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2016.
DescriptionXV, 483 p. 295 illus., 208 illus. in color : online resource
Abstract NoteThis book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines
ISBN,Price9783319308524
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. MOLECULAR BIOLOGY 9. Molecular Medicine 10. Pharmaceutical Sciences/Technology 11. Pharmaceutical technology 12. PHYSICAL CHEMISTRY 13. Protein Structure 14. Proteins?? 15. STATISTICAL PHYSICS
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I09945     On Shelf    

2.     
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TitleMembrane Proteins in Aqueous Solutions : From Detergents to Amphipols
Author(s)Popot, Jean-Luc
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2018.
DescriptionXXVII, 708 p. 437 illus., 266 illus. in color : online resource
Abstract NoteMembrane proteins represent about one third of the proteins encoded in a cell's genome, and, because of their key physiological roles, more than half of drug targets. Detergents are traditionally used to extract proteins from membranes in order to make them amenable to the tools of biochemistry and biophysics. However, detergent-solubilized proteins are generally unstable. This has led to the development of alternative, non-conventional surfactants, such as bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants, and specially designed amphipathic polymers called 'amphipols'. These novel tools, mainly developed over the past 20 years, are revolutionizing handling membrane proteins in vitro for basic and applied research, as well as for such biomedical applications as drug screening or vaccination. This book, written by a specialist of membrane proteins and one of the creators of amphipols, describes the properties and uses of these novel molecules. It opens with general introductions on membrane proteins and their natural environment, detergents, the current status of membrane protein in vitro studies, a broad panorama of non-conventional surfactants and a discussion of their respective advantages and limitations, and the preparation and properties of amphipols and membrane protein/amphipol complexes. Topical chapters cover in vitro folding, cell-free synthesis and stabilization of membrane proteins, and such biophysical and biochemical applications as electron microscopy, Xray diffraction, NMR, optical spectroscopy, mass spectrometry, the whole range of solutions studies, proteomics, and such practical applications as membrane protein immobilization and drug screening and the use of amphipols in vivo for vaccination and drug delivery. Each topical chapter is introduced with a concise, up-to-date overview of how membrane proteins are currently studied using each individual technique, before offering an exhaustive coverage and in-depth discussion of the contribution of amphipols, and concluding with hands-on protocols written by everyday practitioners of each application. In addition to a comprehensive coverage of the properties and uses of non-conventional surfactants, this book therefore also offers a concise, accessible introduction to membrane protein biochemistry and biophysics. It is meant to be used both in basic and applied research laboratories and as a teaching help
ISBN,Price9783319731483
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. Medicinal chemistry 7. Pharmaceutical Sciences/Technology 8. Pharmaceutical technology 9. PHYSICAL CHEMISTRY 10. Polymer Sciences 11. Polymers???? 12. Protein Science 13. Proteins??
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3.     
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TitleNitroxides : Brief History, Fundamentals, and Recent Developments
Author(s)Likhtenshtein, Gertz I
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2020.
DescriptionXI, 316 p : online resource
Abstract NoteWritten by a pioneer in the development of spin labeling in biophysics, this expert book covers the fundamentals of nitroxide spin labeling through cutting-edge applications in chemistry, physics, materials science, molecular biology, and biomedicine. Nitroxides have earned their place as one of the most popular organic paramagnets due to their suitability as inhibitors of oxidative processes, as a means to polarize magnetic nuclei, and, in molecular biology, as probes and labels to understand molecular structures and dynamics as drags for cancer and other diseases. Beginning with an overview of the basic methodology and nitroxides??? 145-year history, this book equips students with necessary background and techniques to undertake original research and industry work in this growing field
ISBN,Price9783030348229
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. Electronic materials 7. MAGNETIC MATERIALS 8. MAGNETISM 9. Magnetism, Magnetic Materials 10. Optical and Electronic Materials 11. OPTICAL MATERIALS 12. Pharmaceutical Sciences/Technology 13. Pharmaceutical technology 14. Polymer Sciences 15. Polymers???? 16. Protein Science 17. Proteins??
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I08904     On Shelf    

4.    
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TitleSpace Pharmacology
Author(s)Wotring, Virginia E
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2012.
DescriptionXI, 109 p. 23 illus., 9 illus. in color : online resource
Abstract Note???Space Pharmacology??? is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights. It is a comprehensive review of the literature, addressing each area of pharmacokinetics and each major physiological system in turn. Every section begins with a topic overview, and is followed by a discussion of published data from spaceflight, and from ground experiments meant to model the spaceflight situation. Includes a discussion looking forward to the new medical challenges we are likely to face on longer duration exploration missions. This book is a snapshot of our current knowledge that also highlights areas of unknown
ISBN,Price9781461433965
Keyword(s)1. EBOOK 2. EBOOK - SPRINGER 3. INORGANIC CHEMISTRY 4. Pharmaceutical Sciences/Technology 5. Pharmaceutical technology 6. SPACE SCIENCES 7. Space Sciences (including Extraterrestrial Physics, Space Exploration and Astronautics)
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I05696     On Shelf    

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