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 #  AuthorTitleAccn#YearItem Type Claims
1 Popot, Jean-Luc Membrane Proteins in Aqueous Solutions I09698 2018 eBook  
2 Vollmer, Frank Optical Whispering Gallery Modes for Biosensing I09610 2020 eBook  
3 Skulachev, Vladimir P Principles of Bioenergetics I07211 2013 eBook  
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TitleMembrane Proteins in Aqueous Solutions : From Detergents to Amphipols
Author(s)Popot, Jean-Luc
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2018.
DescriptionXXVII, 708 p. 437 illus., 266 illus. in color : online resource
Abstract NoteMembrane proteins represent about one third of the proteins encoded in a cell's genome, and, because of their key physiological roles, more than half of drug targets. Detergents are traditionally used to extract proteins from membranes in order to make them amenable to the tools of biochemistry and biophysics. However, detergent-solubilized proteins are generally unstable. This has led to the development of alternative, non-conventional surfactants, such as bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants, and specially designed amphipathic polymers called 'amphipols'. These novel tools, mainly developed over the past 20 years, are revolutionizing handling membrane proteins in vitro for basic and applied research, as well as for such biomedical applications as drug screening or vaccination. This book, written by a specialist of membrane proteins and one of the creators of amphipols, describes the properties and uses of these novel molecules. It opens with general introductions on membrane proteins and their natural environment, detergents, the current status of membrane protein in vitro studies, a broad panorama of non-conventional surfactants and a discussion of their respective advantages and limitations, and the preparation and properties of amphipols and membrane protein/amphipol complexes. Topical chapters cover in vitro folding, cell-free synthesis and stabilization of membrane proteins, and such biophysical and biochemical applications as electron microscopy, Xray diffraction, NMR, optical spectroscopy, mass spectrometry, the whole range of solutions studies, proteomics, and such practical applications as membrane protein immobilization and drug screening and the use of amphipols in vivo for vaccination and drug delivery. Each topical chapter is introduced with a concise, up-to-date overview of how membrane proteins are currently studied using each individual technique, before offering an exhaustive coverage and in-depth discussion of the contribution of amphipols, and concluding with hands-on protocols written by everyday practitioners of each application. In addition to a comprehensive coverage of the properties and uses of non-conventional surfactants, this book therefore also offers a concise, accessible introduction to membrane protein biochemistry and biophysics. It is meant to be used both in basic and applied research laboratories and as a teaching help
ISBN,Price9783319731483
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. EBOOK 5. EBOOK - SPRINGER 6. Medicinal chemistry 7. Pharmaceutical Sciences/Technology 8. Pharmaceutical technology 9. PHYSICAL CHEMISTRY 10. Polymer Sciences 11. Polymers???? 12. Protein Science 13. Proteins??
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I09698     On Shelf    

2.     
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TitleOptical Whispering Gallery Modes for Biosensing : From Physical Principles to Applications
Author(s)Vollmer, Frank;Yu, Deshui
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2020.
DescriptionXIII, 416 p. 139 illus : online resource
Abstract NoteThis interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light???matter interaction, and biomolecular structure with a focus on applications in biosensing. Novel biosensors based on the hybridization of WGM microcavities and localized surface plasmon resonances (LSPRs) in metal nanoparticles have emerged as the most sensitive microsystem biodetection technology that boasts single molecule detection capability without the need for amplification and labeling of the analyte. The book provides an ample survey of the physical mechanisms of WGMs and LSPRs for detecting affinity, concentration, size, shape and orientation of biomarkers, while informing the reader about different classes of biomolecules, their optical properties and their importance in label-free clinical diagnostics. For the more advanced reader, advanced applications of WGMs and LSPRs in exploring the fundamental nature of quantum physics are discussed.
ISBN,Price9783030602352
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. Biotechnology 7. EBOOK 8. EBOOK - SPRINGER 9. MATERIALS SCIENCE 10. Materials Science, general 11. Medicinal chemistry
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I09610     On Shelf    

3.    
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TitlePrinciples of Bioenergetics
Author(s)Skulachev, Vladimir P;Bogachev, Alexander V;Kasparinsky, Felix O
PublicationBerlin, Heidelberg, 1. Imprint: Springer 2. Springer Berlin Heidelberg, 2013.
DescriptionXVI, 436 p : online resource
Abstract NotePrinciples of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry.??Bioenergetics concerns energy transductions occurring in living systems and??this book pays special attention to molecular mechanisms of these processes.??The main subject of the book is the "energy coupling membrane" which refers to??inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases)??are also part of this membrane.??Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants
ISBN,Price9783642334306
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOPHYSICS 4. CELL BIOLOGY 5. EBOOK 6. EBOOK - SPRINGER 7. Geriatrics 8. Geriatrics/Gerontology 9. Medicinal chemistry 10. PHYSICAL CHEMISTRY
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I07211     On Shelf    

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