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 #  AuthorTitleAccn#YearItem Type Claims
1 Thiriet, Marc Vasculopathies I09702 2018 eBook  
2 Colman, Michael A Mechanisms of Atrial Arrhythmias I07694 2014 eBook  
3 Thiriet, Marc Diseases of the Cardiac Pump I07484 2015 eBook  
4 Adeniran, Ismail Modelling the Short QT Syndrome Gene Mutations I07358 2014 eBook  
5 Solaro, R. John Biophysics of the Failing Heart I07310 2013 eBook  
6 Thiriet, Marc Control of Cell Fate in the Circulatory and Ventilatory Systems I07109 2012 eBook  
7 Thiriet, Marc Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems I07055 2013 eBook  
8 Zaidi, Habib Quantitative Analysis in Nuclear Medicine Imaging I06705 2006 eBook  
9 Thiriet, Marc Biology and Mechanics of Blood Flows I06679 2008 eBook  
10 Bittihn, Philip Complex Structure and Dynamics of the Heart I06672 2015 eBook  
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1.    
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TitleVasculopathies : Behavioral, Chemical, Environmental, and Genetic Factors
Author(s)Thiriet, Marc
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2018.
DescriptionXXXIII, 888 p. 6 illus : online resource
Abstract NoteThis volume presents one of the clinical foundations of vasculopathies: the biological markers and risk factors associated with cardiovascular disease. A detailed biological and clinical framework is provided as a prerequisite for adequate modeling. Chapter 1 presents cardiovascular risk factors and markers, where the search for new criteria is aimed at improving early detection of chronic diseases. The subsequent chapters focus on hypertension, which involves the kidney among other organs as well as many agents, hyperglycemia and diabetes, hyperlipidemias and obesity, and behavior. The last of these risk factors includes altered circadian rhythm, tobacco and alcohol consumption, physical inactivity, and diet. The volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms
ISBN,Price9783319893150
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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2.     
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TitleMechanisms of Atrial Arrhythmias : Insights from the Development of a Biophysically Detailed Model of the Human Atria
Author(s)Colman, Michael A
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2014.
DescriptionXXII, 256 p. 137 illus., 42 illus. in color : online resource
Abstract NoteThis thesis describes the??development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common??causes of??morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation.?? The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and??develops novel techniques for the monitoring of atrial tachycardia.??
ISBN,Price9783319016436
Keyword(s)1. Bioinformatics?? 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. CARDIOLOGY 6. Computational biology?? 7. Computer Appl. in Life Sciences 8. EBOOK 9. EBOOK - SPRINGER 10. Mathematical Applications in the Physical Sciences 11. MATHEMATICAL PHYSICS 12. Numerical and Computational Physics, Simulation 13. PHYSICS
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3.     
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TitleDiseases of the Cardiac Pump
Author(s)Thiriet, Marc
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2015.
DescriptionXVI, 631 p. 7 illus., 1 illus. in color : online resource
Abstract NoteTogether, the volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanism. Therefore, investigation of flows of blood and air in anatomical conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning in quantitative terms. The present volume focuses on macroscopic aspects of the cardiovascular and respiratory systems in pathological conditions, i.e., diseases of the cardiac pump, blood vessels, and airways, as well as their treatments. Only diseases that have a mechanical origin or are associated with mechanical disorders are covered. Local flow disturbances can trigger pathophysiological processes or, conversely, result from diseases of conduit walls or their environment. The ability to model these phenomena is essential to the development and manufacturing of medical devices, which incorporate a stage of numerical tests in addition to experimental procedures
ISBN,Price9783319126647
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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TitleModelling the Short QT Syndrome Gene Mutations : And Their Role in Cardiac Arrhythmogenesis
Author(s)Adeniran, Ismail
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2014.
DescriptionXVII, 217 p. 102 illus., 38 illus. in color : online resource
Abstract NoteThe Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.?? The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as ???outstanding.???
ISBN,Price9783319072005
Keyword(s)1. Biological systems 2. CARDIOLOGY 3. Cell membranes?? 4. COMPLEX SYSTEMS 5. DYNAMICAL SYSTEMS 6. EBOOK 7. EBOOK - SPRINGER 8. Membrane Biology 9. Numerical and Computational Physics, Simulation 10. PHYSICS 11. STATISTICAL PHYSICS 12. Statistical Physics and Dynamical Systems 13. Systems biology
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5.     
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TitleBiophysics of the Failing Heart : Physics and Biology of Heart Muscle
Author(s)Solaro, R. John;Tardiff, Jil C
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2013.
DescriptionVI, 253 p : online resource
Abstract NoteBiophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels
ISBN,Price9781461476788
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. CARDIOLOGY 7. EBOOK 8. EBOOK - SPRINGER 9. Medical and Radiation Physics 10. Medical physics 11. RADIATION
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6.     
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TitleControl of Cell Fate in the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2012.
DescriptionX, 538 p : online resource
Abstract NoteThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volumes??1 and 2??are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment.??Volume 1??examined cellular features that allow adaptation to environmental conditions.??Volume 2??begins with a survey of the cell types of the nervous and endocrine systems involved in the regulation of the vasculature and respiratory tract and growth factors.?? It then describes major cell events in the circulatory and ventilatory systems, such as cell growth, proliferation, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered. Describes cell types, functions, and fate in the regulated activities of the circulatory and respiratory systems Presents applications of mechanics and mathematics for an understanding and prediction of function in health and disease Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
ISBN,Price9781461403296
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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7.     
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TitleIntracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Author(s)Thiriet, Marc
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2013.
DescriptionXV, 1064 p. 31 illus : online resource
Abstract NoteThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.?? Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.?? Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
ISBN,Price9781461443704
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. BIOMATHEMATICS 4. Biomedical engineering 5. Biomedical Engineering and Bioengineering 6. BIOPHYSICS 7. CARDIOLOGY 8. EBOOK 9. EBOOK - SPRINGER 10. Engineering Fluid Dynamics 11. FLUID MECHANICS 12. Mathematical and Computational Biology 13. Systems biology
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8.     
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TitleQuantitative Analysis in Nuclear Medicine Imaging
Author(s)Zaidi, Habib
PublicationNew York, NY, 1. Imprint: Springer 2. Springer US, 2006.
DescriptionXI, 583 p. 166 illus., 56 illus. in color : online resource
Abstract NoteThis book provides a review of image analysis techniques as they are applied in the field of diagnostic and therapeutic nuclear medicine. Driven in part by the remarkable sophistication of nuclear medicine instrumentation and - crease in computing power and its ready and inexpensive availability, this is a relatively new yet rapidly expanding field. Likewise, although the use of nuclear imaging for diagnosis and therapy has origins dating back almost to the pioneering work of Dr G. de Hevesy, quantitative imaging has only recently emerged as a promising approach for diagnosis and therapy of many diseases. An effort has, therefore, been made to place the reviews provided in this book in a broader context. The effort to do this is reflected by the inclusion of introductory chapters that address basic principles of nuclear medicine instrumentation and dual-modality imaging, followed by overview of issues that are closely related to quantitative nuclear imaging and its potential role in diagnostic and therapeutic applications. A brief overview of each chapter is provided below. Chapter 1 presents a general overview of nuclear medicine imaging physics and instrumentation including planar scintigraphy, single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Nowadays, patients??? diagnosis and therapy is rarely done without the use of imaging technology. As such, imaging considerations are incorporated in almost every chapter of the book. The development of dual-modality - aging systems is an emerging research field, which is addressed in chapter 2
ISBN,Price9780387254449
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. CARDIOLOGY 7. EBOOK 8. EBOOK - SPRINGER 9. Neurosciences 10. ONCOLOGY 11. Oncology???? 12. PHARMACOLOGY 13. Pharmacology/Toxicology
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9.     
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TitleBiology and Mechanics of Blood Flows : Part II: Mechanics and Medical Aspects
Author(s)Thiriet, Marc
PublicationNew York, NY, 1. Imprint: Springer 2. Springer New York, 2008.
DescriptionXII, 468 p : online resource
Abstract NoteBiology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part II of this two-volume sequence, Mechanics and Medical Aspects, refers to the extraction of input data at the macroscopic scale for modeling the cardiovascular system, and complements Part I, which focuses on nanoscopic and microscopic components and processes. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases. This authoritative book will appeal to any biologist, chemist, physicist, or applied mathematician interested in the functioning of the cardiovascular system
ISBN,Price9780387748498
Keyword(s)1. Biological and Medical Physics, Biophysics 2. BIOLOGICAL PHYSICS 3. Biomedical engineering 4. Biomedical Engineering and Bioengineering 5. BIOPHYSICS 6. CARDIOLOGY 7. EBOOK 8. EBOOK - SPRINGER 9. MECHANICS 10. Mechanics, Applied 11. Solid Mechanics
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10.    
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TitleComplex Structure and Dynamics of the Heart
Author(s)Bittihn, Philip
PublicationCham, 1. Imprint: Springer 2. Springer International Publishing, 2015.
DescriptionXV, 204 p. 69 illus., 47 illus. in color : online resource
Abstract NoteThis award-winning thesis investigates the mechanisms underlying cardiac arrhythmia development and termination from an entirely new perspective. By viewing the heart as a complex system, the author uses theoretical tools from nonlinear dynamics combined with numerical simulations and experiments to achieve insights into the relationship between its structure and dynamics, thereby paving the way towards innovative low-energy defibrillation strategies. The work tackles, among other things: the effect of substrate heterogeneity on the spatial-temporal dynamics of cardiac arrhythmias and ways in which weak pulsed electric fields can be used to control these dynamics in heterogeneous cardiac tissue. The long-term vision of this research is to replace the current strategy of applying painful and sometimes tissue damaging electric shock ??? currently the only reliable way to terminate life-threatening fibrillation ??? by a more subtle but equally effective intervention. The book maps out a number of promising research directions for biophysicists and medical researchers working on the origins and treatment of cardiac arrhythmias
ISBN,Price9783319122328
Keyword(s)1. Applications of Nonlinear Dynamics and Chaos Theory 2. Biological and Medical Physics, Biophysics 3. BIOLOGICAL PHYSICS 4. BIOPHYSICS 5. CARDIOLOGY 6. EBOOK 7. EBOOK - SPRINGER 8. Numerical and Computational Physics, Simulation 9. PHYSICS 10. STATISTICAL PHYSICS
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